Our Technology

Homogeneous, glyco-engineered conjugates for safer, more potent antibody therapeutics.

Our site-specific conjugation platform delivers ADCs with enhanced stability, more precise DAR control, and improved clinical predictability compared to traditional conjugation methods, enabling more effective and targeted treatments for patients.

How It Works

1.

Glycan Remodeling

Highly engineered glycosidases precisely modify Fc-region glycans, creating uniform conjugation sites.

2.

Payload Attachment

Cytotoxic payloads are conjugated at these sites, delivering a tightly controlled drug-to-antibody ratio (DAR).

3.

Homogeneous ADCs

The reaction produces ADCs with consistent DAR and minimal aggregation, ensuring product uniformity.

4.

Clinic-Ready Quality

Rigorous testing confirms high consistency and reproducibility that meet stringent biologics regulations.

Benefits That Matter

Development Efficiency

A highly active glycosynthase prepares the antibody for conjugation in one pot shortening production timelines and improving yield.
The key sugar is synthesized without bottlenecks, enabling smooth transition from bench to pilot plant.

Product Performance

Payloads attach only to the selectively remodeled Fc glycan, producing uniform ADCs with programmable DAR options (2, 4, 6, 8).
Proven compatibility with MMAE, DM1, exatecan and other cytotoxins. No antibody re-engineering is required.

Why Enzymatic Glycoengineering Outperforms Conventional Conjugation

Xcellon’s enzymatic glyco-engineering (EG) platform delivers tangible advantages that conventional chemical conjugation cannot match.

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Faster development cycles, lower manufacturing risk, and highly consistent, clinic-ready ADCs.

Accelerate Your Pipeline with Stronger therapeutic windows and clearer regulatory paths.

Leverage Xcellon’s enzymatic glyco-engineering and end-to-end development services to put these advantages to work for your program.

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Xcellon Biologics is backed by successful biotech entrepreneurs and professionals from top pharmaceutical and CDMO companies including Lonza, Abzena, Amgen, MedImmune, AstraZeneca, BioNTech, Seattle Genetics, and Immunomedics.

We collaborate with leading innovators and global partners to accelerate biopharmaceutical breakthroughs while maintaining the highest quality and regulatory standards.