Bioprocess Development
with ADC-Integrated DSP Platforms

Xcellon Biologics delivers Bioprocess Development services designed for biologics and ADCs. Unlike traditional CDMOs, we don’t stop at upstream optimization, our services integrate conjugation workflows with a platform downstream purification (DSP) process specifically tailored for ADCs. This ensures scalable processes with consistent quality and reproducibility, reducing risks during GMP transfer.

What’s at Stake in Bioprocessing

Conventional development strategies often fall short for ADC programs. Protein engineering and upstream processes may deliver high expression, but without optimized conjugation and purification, programs risk free payload carryover, aggregation, and variability.

Integrated services covering protein engineering, upstream optimization, flexible conjugation strategies, platform DSP purification, process characterization, and tech transfer readiness enable scalable, reproducible workflows designed for CMC success and smooth IND advancement.

What We Offer

Protein Engineering and Antibody Development
Gene cloning, mutagenesis, ORF optimization, antibody format engineering, Antigen production, epitope binding, in-silico modeling, internalization assays
Cell Line Generation
Stable pool generation, clone selection, banking, expression optimization
Upstream process optimization
Media/feed strategy development, cell culture optimization, DoE-based bioreactor studies
Platform DSP purification
Robust clearance of free payloads, impurities, and aggregates. Fully integrated into typical antibody purification workflow.
Process characterization
Identification of critical parameters and risk factors for scale-up by DoE, process risk assessment
Tech transfer readiness
Scalable protocols designed for smooth handoff into GMP.

Integrated ADC Purification Platform

Our bioprocess workflows directly support ADC development services, ensuring conjugation methods translate into scalable processes. They also prepare the foundation for future GMP manufacturing capabilities, reducing risk during clinical supply. Insights from analytical and formulation development feed back into process design, ensuring stability and DAR consistency are monitored throughout.

Build ADC processes with reproducibility and scalability in mind

Design ADC processes for high reproducibility and scalability, ensuring consistent conjugate quality. Optimize workflows to support seamless scale-up from lab to production. Implement standardized protocols to maintain efficiency, accuracy, and regulatory compliance.

FAQs for Bioprocess development

What makes Xcellon’s bioprocess development unique?

We integrate conjugation strategies with a platform DSP designed for ADCs, ensuring robust clearance of free payloads, aggregates, and impurities while maintaining scalability.

How is DSP integrated into your bioprocess workflows?

Our DSP platform is fully integrated into standard antibody purification workflows, meaning ADC-specific purification steps slot directly into established downstream processes. This ensures efficiency, reproducibility, and smooth GMP tech transfer.

How do you control DAR and reduce variability in processes?

Our glycoengineering platform enables site-specific DAR control (2, 4, 6, or 8) with high reproducibility. For programs requiring flexibility, we also offer cysteine, lysine, enzymatic, and click chemistries , all supported by DSP platform for batch-to-batch consistency.