Bioprocess Development
with ADC-Integrated DSP Platforms
Xcellon Biologics delivers Bioprocess Development services designed for biologics and ADCs. Unlike traditional CDMOs, we don’t stop at upstream optimization, our services integrate conjugation workflows with a platform downstream purification (DSP) process specifically tailored for ADCs. This ensures scalable processes with consistent quality and reproducibility, reducing risks during GMP transfer.
What’s at Stake in Bioprocessing
Conventional development strategies often fall short for ADC programs. Protein engineering and upstream processes may deliver high expression, but without optimized conjugation and purification, programs risk free payload carryover, aggregation, and variability.
Integrated services covering protein engineering, upstream optimization, flexible conjugation strategies, platform DSP purification, process characterization, and tech transfer readiness enable scalable, reproducible workflows designed for CMC success and smooth IND advancement.
What We Offer
- Cell line development
- Upstream process development
- Platform DSP purification
- Process characterization
- Technology transfer
Capabilities
- CYTENA single cell printer
- Beckman Coulter Biomek
- Sartorius Ambr 15
- Sartorius Ambr 250
- Eppendorf BioFlo 320
- Sartorius 200L bioreactor
- Cytiva ÄKTA Avant & Pilot
- TECAN liquid handler
- Repligen TFF systems
Integrated ADC Purification Platform
- Fully integrated to traditional antibody purification workflow
- Scalable platform for seamless tech transfer and CMC development
- Compatible with latest single use technologies
- Demonstrated to meet all ADC drug substance release criteria
Our bioprocess workflows directly support ADC development services, ensuring conjugation methods translate into scalable processes. They also prepare the foundation for future GMP manufacturing capabilities, reducing risk during clinical supply. Insights from analytical and formulation development feed back into process design, ensuring stability and DAR consistency are monitored throughout.
Build ADC processes with reproducibility and scalability in mind
FAQs for Bioprocess development
We integrate conjugation strategies with a platform DSP designed for ADCs, ensuring robust clearance of free payloads, aggregates, and impurities while maintaining scalability.
Our DSP platform is fully integrated into standard antibody purification workflows, meaning ADC-specific purification steps slot directly into established downstream processes. This ensures efficiency, reproducibility, and smooth GMP tech transfer.
Our glycoengineering platform enables site-specific DAR control (2, 4, 6, or 8) with high reproducibility. For programs requiring flexibility, we also offer cysteine, lysine, enzymatic, and click chemistries , all supported by DSP platform for batch-to-batch consistency.
