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We specialize in cutting-edge biologics development to help our partners bring life-saving therapies to patients faster and more efficiently. Our expertise spans antibody drug conjugates (ADCs) and bioconjugate development, bioprocess development, analytical and formulation development services.

  • ADC & Bioconjugate Lead Selection

Rapidly identify optimal ADC / bioconjugate candidates using our modular toolbox. We streamline payload, linker, and conjugation strategy evaluation to accelerate early-stage decision-making.

  • Conjugation Strategies
    Lysine conjugation, cysteine conjugation, enzyme-catalyzed conjugation, incorporation of non-natural amino acid, click chemistry approaches
  • Payloads
    Topoisomerase inhibitors, microtubule inhibitors, DNA-damaging payloads, PROTACs, protein degraders, immunoregulatory payloads
  • Linker Technologies
    Non-cleavable linkers, cathepsin-sensitive linkers, lysosome-dependent linkers
  • Cytotoxicity Testing & Analytical Evaluation
    Cytotoxicity assays, conjugate biophysical characterization
  • Material Generation for In-Vivo Studies
    Small scale conjugation runs, analytical characterization of materials
  • ADC & Bioconjugate Development
From conjugation optimization to preclinical material generation, we deliver scalable, robust processes with deep analytical support to move you confidently toward IND readiness.
  • Developability Assessment
    In-depth characterizations of conjugates, thermal and serum stability assessments
  • Conjugation Optimization through Design-of-Experiment (DoE)
    Rapid identification of optimal conjugation parameters across multiple variables
  • Post-Conjugation Purification Process Optimization
    Development and optimize scalable and robust purification process for GMP manufacturing
  • Tox Material Generation
    Medium scale conjugation runs for tox studies
  • Stability Studies
    Long-term, accelerated and stressed conditions
  • Bioprocess Development Services

Comprehensive biologics development support. We integrate protein engineering, process development and optimization for efficient scale-up and technology transfer.

  • Antibody Development & Characterization
    Antigen production, epitope binding, in-silico modeling, internalization assays
  • Protein Engineering
    Gene cloning, mutagenesis, ORF optimization, antibody format engineering
  • Cell Line Generation
    Stable pool generation, clone selection, banking, expression optimization
  • Upstream & Downstream Process Development & Characterization
    Media and feed strategy optimization, DoE for bioreactor and purification process development and characterization, process risk assessment
  • Analytical & Formulation Development

We provide advanced analytical, formulation services and stability testing to support the comprehensive evaluation of  biologics and bioconjugates. Our capabilities include:

  • Characterization & Identity Testing
    Deglycosylated and reduced mass analysis, disulfide bond analysis, conjugation site confirmation, N-glycan profiling, tertiary structure, molecular species distribution, thiol content, peptide mapping
  • Purity & Impurity Analysis
    Aggregate and fragment analysis, % monomer content, heavy and light chain profiling (reducing/non-reducing), unconjugated antibody, free drug, residuals
  • Safety & General Testing
    Endotoxin, osmolarity, pH & conductivity
  • Potency & Stability Testing
    DAR, biolayer interferometry, thermal stability, long-term, accelerated and stressed conditions
  • Formulation Development
    Buffer selection, excipient screening, freeze/thaw studies, accelerated stability
  • Advanced Data Analytics and Machine Learning
Xcellon leverages advanced analytics and machine learning to enhance process understanding, troubleshoot issues, and improve development efficiency.
  • Integration of Data Analytics
    Consolidation of multi-source data to generate actionable process insights
  • Implementation of Advanced Statistical Methods
    Multivariate analysis and statistical modeling for process monitoring and control
  • Development of Data-Driven Models
    Predictive models for process optimization and performance improvement
  • Application of Machine Learning (ML) Techniques
    ML algorithms to identify trends, reduce variability, and enhance process predictability
  • Future GMP Manufacturing Capabilities
Coming Soon.
End-to-end GMP manufacturing capabilities to be available by 2026.

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Xcellon Biologics is backed by successful biotech entrepreneurs and professionals from top pharmaceutical and CDMO companies including Lonza, Abzena, Amgen, MedImmune, AstraZeneca, BioNTech, Seattle Genetics, and Immunomedics.

We collaborate with leading innovators and global partners to accelerate biopharmaceutical breakthroughs while maintaining the highest quality and regulatory standards.
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